发给老马备查:
6 I% h1 V/ {3 K滴水察海(69304838) 15:23:238 `5 @" i* G/ ~4 g# H0 [. g
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
9 J' P/ R) [( \: J4 X6 T吉非替尼和S-1连用的依据
! I0 @2 P2 z4 \* }1 gGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
+ b6 z/ N0 F" D) z+ A% N是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
9 G# h7 ^4 G% I; c5 h, I这样是不是推理出,耐药后,可以用S-1和培美了?
. x$ R, X1 Z7 I% Y/ E9 U+ b结论:
- l! @& j& F8 r6 o4 Z如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |