请前辈给些治疗指导
5月初和今天做的腹部彩超，今天比5月初还变大了，是不是说明目前的治疗方案不起效，从5月12日起方案为奥希（一天一粒）十安罗（两天一粒10mg），人的状态不好，食欲差，刚用胸水做了基因检测，结果如下http://oss.yuaigongwu.com/pic/20220524/1653385628331799_784.jpg
http://oss.yuaigongwu.com/pic/20220524/1653385628339138_911.jpg
http://oss.yuaigongwu.com/pic/20220524/1653385628340953_476.jpg
http://oss.yuaigongwu.com/pic/20220524/1653385628341192_745.jpg
http://oss.yuaigongwu.com/pic/20220524/1653385628342307_354.jpg
http://oss.yuaigongwu.com/pic/20220524/1653385628343329_356.jpg
http://oss.yuaigongwu.com/pic/20220524/1653385628344380_45.jpg
http://oss.yuaigongwu.com/pic/20220524/1653385628344142_892.jpg
http://oss.yuaigongwu.com/pic/20220524/1653385628421458_798.jpg
培美曲塞+阿法替尼（脑转移达克替尼）+贝伐单抗
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