墨尔本科研人员发现治疗肺癌的突破性药物

应该是白介素6信号抑制剂，药品名称sgp130FC，给我的直观感觉是和免疫治疗直接相关的。可以关注一下。

原文链接：http://tenplay.com.au/news/natio ... gh-lung-cancer-drug

原文如下：

There’s new hope for lung cancer suffers and those at risk of developing the disease.

Melbourne researchers have discovered a breakthrough new drug that could potentially stop lung cancer or emphysema as well as detecting the disease before it spreads through the body.

The life-saving discovery was made by researchers from Melbourne’s Hudson Institute of Medical Science who identified an inflammation-causing molecule that triggers the disease.

The drug, which is currently undergoing clinical human trials to fight inflammatory bowel disease in Europe, appears to shut down the signalling system responsible for developing lung cells.

The breakthrough discovery offers hope to the 15,000 Australians who die of lung cancer each year.

Blood tests have already been developed to help researchers unlock ways to detect the molecule Interleukin 6 or II-6, which is linked to the diseases.

Lead researcher Professor Brendan Jenkins said screening may one day be able to detect the disease before the danger is “switched on”.

“The beauty of the two studies we have done is that we have shown that yes, the molecule is increased in the blood and tissue biopsies, but importantly we have shown that if you target Il-6 and block it you will see a suppression of disease in both lung cancer and emphysema,” Prof Jenkins said.

“Importantly, we have now identified the way of targeting Il-6.”

The experimental drug donned ‘sgp130FC’ has shown promising signs during animal trials, in terms of stemming the signalling process in lung cancer and emphysema.

The drug is designed to bind to the II-6 molecule which in turn blocks the molecule from attaching itself to lung cells.

It therefore can’t pass on signals to grow or self-destruct.

“You see a dramatic reduction in the amount of tumours forming — they just don’t seem to grow anywhere near as well as the tumours would if sgp130Fc was not there,” Prof Jenkins said.

“It is very effective at blocking and retarding the growth of these tumours.

“The more amazing thing is that if you treat an animal just before they would normally start to develop emphysema, the mice just don’t develop the disease at all.

“It blocks it completely and there is no emphysema at all.”

Researchers are now working to further develop the blood test for both diseases.

看不懂英文，有人翻译一下就好了。

一种药sgp130FC  ，目前在欧洲进行肠炎的临床试验，表现出了对肺细胞进展的阻断作用。
一个叫Interleukin 6 或 II-6的东东可以通过血液检测出来，sgp130FC  就是通过阻止II-6与肺细胞结合，从而阻断相关信号，使癌细胞无法生长或自杀。可以有效的阻止或延迟肿瘤生长。在动物上的试验效果很好

erichhartman 发表于 2016-7-26 18:41
一种药sgp130FC  ，目前在欧洲进行肠炎的临床试验，表现出了对肺细胞进展的阻断作用。
一个叫Interleukin  ...

抗IL-6具有抗炎效果。关注这项研究进展。

墨尔本的研究人员发现了一个突破性的新药物，可以阻止肺癌或肺气肿以及传播通过之前的身体疾病的检测。

救命的发现是由来自墨尔本的哈德逊研究所医学认为引起分子引发的疾病炎症者。

的药物，目前正在进行临床人体试验在欧洲对抗炎症性肠病，似乎关闭信号系统负责开发肺细胞。

这个突破性的发现提供了希望15000澳大利亚人每年死于肺癌。

血液测试已经发展到帮助研究人员解开检测分子白细胞介素6或IL-6的方式，这是与疾病。

首席研究员Brendan Jenkins教授说，筛查可能有一天能够检测疾病的危险是在“打开”。

“这两个研究我们所做的是美丽的，我们已经表明，是的，该分子在血液和组织活检增加，但重要的是我们已经证明，如果你的目标是IL-6和块它你将看到在肺癌和肺气肿的抑制疾病，”詹金斯教授说。

“重要的是，我们现在已经确定的靶细胞的方式。”

实验药物上的sgp130fc”已显示出可喜的迹象，在动物试验中，在阻止信号过程中肺癌和肺气肿的条款。

药物是用来绑定到IL-6分子反过来阻止分子附着于肺细胞。

因此，不能把信号成长或自我毁灭。

“你看到在肿瘤形成的量大幅减少，但他们似乎并不长接近以及肿瘤如果sgp130fc还不存在，”詹金斯教授说。

“这是非常有效的阻止和抑制这些肿瘤的生长。

“更令人惊奇的是，如果你对一个动物之前，他们通常会开始出现肺气肿，老鼠根本不发病。

“那块完全没有肺气肿的一切。”

研究人员正在进一步发展为疾病的血液测试。

百度翻译的，结合原文能看懂个大概

但是实际应用还有很长的时间，对于我来说只是科幻故事

希望能尽快进入临床。

好人好运 发表于 2016-7-26 21:41
墨尔本的研究人员发现了一个突破性的新药物，可以阻止肺癌或肺气肿以及传播通过之前的身体疾病的检测。

...

谢谢